Experimental study of skin-sensitizing antibodies after aerosol and subcutaneous immunization

The reaction of passive skin anaphylaxis was used to investigate the accumulation and the dynamics of skin-sensitizing antibodies (SSA) in the sera of guinea pigs immunized with botulin anatoxin by means of different methods: the aerosol and the subcutaneous method. In the aerosol-immunized animals (unlike the subcutaneously immunized ones) SSA appeared in a negligible amount only after the fourth immunization and disappeared rapidly.