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[Prolactin level in congenital adrenal cortex dysfunction]

I G Romazanovich, E Z Gincherman, I V Golubeva

    Problemy Endokrinologii
    |May 1, 1980
    PubMed
    Summary
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    Congenital adrenal cortex dysfunction often leads to high prolactin levels in untreated patients. Glucocorticosteroid treatment can normalize prolactin, but elevated levels may persist with ovarian dysfunction.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Pediatric Endocrinology

    Context:

    • Congenital adrenal cortex dysfunction (CACD) is a group of genetic disorders affecting cortisol production.
    • Hyperprolactinemia is a common endocrine abnormality with various underlying causes.
    • Ovarian function disturbances are frequently observed in women with CACD.

    Purpose:

    • To investigate the relationship between prolactin secretion and congenital adrenal cortex dysfunction.
    • To evaluate the effect of glucocorticosteroid therapy on prolactin levels in CACD patients.
    • To explore the impact of persistent ovarian dysfunction on prolactin levels despite treatment.

    Summary:

    • Elevated blood prolactin levels were observed in the majority of untreated patients with CACD.

    Related Experiment Videos

  • Glucocorticosteroid treatment resulted in a decrease in blood prolactin levels.
  • Hyperprolactinemia persisted in some CACD patients on glucocorticosteroids, particularly those with ongoing ovarian function disturbances, irrespective of 17-CS excretion levels.

    • Impact:

    • Highlights the significant association between CACD and hyperprolactinemia.
    • Demonstrates the therapeutic potential of glucocorticosteroids in managing prolactin levels in CACD.
    • Underscores the complex interplay between CACD, glucocorticosteroid treatment, ovarian function, and prolactin regulation.