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2,3-diphosphoglycerate during exercise

J Böswart, I Kuta, Z Lisý

    European Journal of Applied Physiology and Occupational Physiology
    |January 1, 1980
    PubMed
    Summary

    Physical exercise significantly increases erythrocyte 2,3-diphosphoglycerate (2,3-DPG) levels in trained athletes. Intense training over six months further elevates 2,3-DPG and other key physiological markers.

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    Area of Science:

    • Sports Medicine
    • Physiology
    • Biochemistry

    Background:

    • Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) plays a crucial role in oxygen transport.
    • The impact of intense physical exercise on 2,3-DPG levels in athletes is of significant interest.

    Purpose of the Study:

    • To investigate the effect of a single bout of intense exercise on 2,3-DPG levels.
    • To assess the long-term impact of six months of intense training on 2,3-DPG and related physiological parameters in trained canoeists.

    Main Methods:

    • Eight trained speed canoeists (aged 15-25) underwent a 4-minute paddling ergometer test.
    • Cardiorespiratory parameters (VO2, HR, etc.), blood lactate, haematocrit, and 2,3-DPG were measured.
    • Measurements were taken at rest and after the exercise bout, with a follow-up after 6 months of training.

    Main Results:

    • A statistically significant increase in resting erythrocyte 2,3-DPG and haematocrit was observed.
    • Following intense exercise, resting 2,3-DPG and haematocrit levels were significantly elevated.
    • After six months of intense training, 2,3-DPG levels showed a significant increase, along with other physiological parameters.

    Conclusions:

    • Intense physical exercise, both acute and chronic, leads to elevated erythrocyte 2,3-DPG levels in trained athletes.
    • These findings suggest an adaptation of oxygen-carrying capacity in response to rigorous training regimens.

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