Presenile Alzheimer disease: amyloid plaques in the cerebellum

Seven of 24 patients with pathologically proved Alzheimer disease had amyloid plaques resembling kuru plaques in the cerebellum. In all seven patients, the dementia was presenile in onset, there was a positive family history of the disease in five patients, and other neurologic symptoms were present in five. Similar plaques have been described in one of two patients with familial Alzheimer disease from whom spongiform encephalopathy was induced in subhuman primates after intracerebral inoculation of brain tissue. These observations suggest that some cases of familial Alzheimer disease may be clinically distinct from senile dementia and may not be genetic in origin.