The relationship of vasodilator activity of adenosine analogs with molecular connectivity and van der Waals volume

A quantitative analysis is made on the relationship of vasodilator activity of adenosine analogs with Kier's molecular connectivity (chi) and van der Waals volume (Vw). In all attempts the most significant correlation that surfaced led to suggest that molecular shape and size of the molecules would be important in their vasodilator activity.