[Toxicology of acemetacin]

Acute toxicity (DL50) of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetoxy]-acetic acid (acemetacin, TV 1322, Rantudil) was determined following different forms of application and in various animal species. Acemetacin was tolerated better than indometacin in all cases. Taking into consideration the anti-inflammatory effect (DE50 kaolin edema) a better therapeutic spectrum of acemetacin could be proved compared to a number of other anti-inflammatory agents on the market. The toxicity was typical for the symptoms of non-steroidal anti-inflammatory agents. During 6 months of chronic feeding studies in rats and monkeys better tolerance of acemetacin was observed. teratogenic effects in rats and rabbits were not traceable.