[Plasma lipoproteins, modifiers of the ionic permeability of artificial lipid membranes]

With the help of BLM a possibility of non-receptor interaction between the blood plasma lipoproteides and isolated apoproteins immediately with the lipid part of plasmic membranes was shown. Incorporation of lipoproteides in BLM is of a cooperative character and induces cationic permeability in them. Specific interactions with the membranes of aterogenic and antiaterogenic classes of lipoproteides, the role of dimensions and surface charge of lipoproteide particles and of apoproteins and calcium ions in the course of incorporation are revealed. It is suggested that asymmetrical incorporation of a lipoproteide particle in the bilayer and a local increase of the membrane permeability for calcium results in the activation of the contractile system of the cortical layer and in the formation of endocytosis vacuole transporting the lipoproteide particles into the cell.