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Skin test reactivity to dog-derived antigens
Clinical Allergy
|May 1, 1980
Summary
Breed-specific canine antigens, including urine and serum, show increased skin test reactivity compared to mixed extracts. This suggests their potential utility in diagnosing dog hypersensitivity in atopic patients and veterinarians.
Area of Science:
- Veterinary Dermatology
- Immunology
- Allergy Testing
Background:
- Atopic individuals, including patients and veterinarians, are frequently exposed to canine allergens.
- Current diagnostic methods for dog hypersensitivity often rely on mixed dander extracts, which may lack specificity.
Purpose of the Study:
- To investigate the diagnostic utility of breed-specific canine antigens beyond conventional dander extracts.
- To compare skin test reactivity to mixed versus breed-specific canine antigens.
Main Methods:
- Skin testing was performed on atopic patients and veterinarians.
- Antigens included a commercial mixed-dog epithelial extract and breed-specific extracts (dander, serum, urine) from 31 pure-bred dogs.
Main Results:
- Breed-specific canine antigens elicited significantly higher skin test reactivity compared to the mixed-dog commercial screening extract.
- Variability in skin test responses was observed across different specific breed antigens.
Conclusions:
- Canine urine and serum antigens, in addition to dander, may enhance the diagnosis of hypersensitivity to dogs.
- Utilizing breed-specific antigens could improve the accuracy of canine allergy testing.