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[Granulocyte and thrombocyte substitution]

P Höcker, E Pittermann, M Mann

Infusionstherapie Und Klinische Ernahrung

|August 1, 1980

Summary

This summary is machine-generated.

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Large-scale platelet and granulocyte production supports patients with bone marrow failure. HLA-compatible donors enable targeted cell therapy for hemorrhage and severe infections.

Area of Science:

Hematology
Transfusion Medicine

Context:

Bone marrow failure necessitates substantial platelet and granulocyte transfusions.
Cell separators allow for apheresis of large quantities of platelets (up to 10 X 10^11) and granulocytes (over 2 X 10^10) per donor.

Purpose:

To outline the indications and procurement strategies for platelet and granulocyte transfusions in supportive care.
To highlight the feasibility of HLA-compatible donor selection for apheresis products.

Summary:

Platelet transfusions are indicated for hemorrhage with decreased production.
Granulocyte transfusions are reserved for severe granulocytopenia (<500/microliter) with life-threatening infections and expected marrow recovery.

Impact:

Optimizes resource allocation for cell therapy.

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Enhances patient outcomes by ensuring appropriate use of critical blood components.

Facilitates the selection of compatible donors for apheresis procedures.