Postural asymmetry and directionality of rotation in rats

The hypothesis [12] that the direction of postural asymmetry can predict rotational side preferences caused by amphetamine, was tested. Postural asymmetry of male and female Wistar rats was assessed using four tests: (a) tail suspension, (b) tail holding, (c) tail pinch, and (d) walking on a narrow path. The tests were conducted prior to and after (+)-amphetamine (1 mg/kg, IP) administration. Rotational directionality was assessed in a rotometer. None of the tests predicted the direction of circling. The findings suggest that there is a multitude of systems contributing to asymmetric posture.