[Comparative experimental characteristics of clonazepam and diazepam]

Among the drugs of the benzodiazepine series, clonazepam shows the highest anticonvulsant activity in experiments on mice and rats. It has the highest activity and selectivity of action according to the subcutaneous antipentylene tetrazol and antithiose-micarbazid tests. Administration of increased doses of clonazepam results in potentiation of its tranquilizing, antiaggressive and sedative effects. The tranquilizing effect exhibited by clonazepam in the conflict situation is similar to that exerted by diazepam. The sedative effect of clonazepam on Müller's labyrinth is more potent compared to diazepam. Unlike diazepam metabolites, that show high activity in experiments, the products of clonazepam biotransformation are less potent.