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Ovarian function in the ewe after active immunization against testosterone

R J Scaramuzzi, D T Baird, N D Martensz

    Journal of Reproduction and Fertility
    |January 1, 1981
    PubMed
    Summary
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    Active immunization against testosterone disrupted oestrous cycles in ewes, leading to ovarian over-stimulation and irregular ovulation. This highlights testosterone

    Area of Science:

    • Reproductive Endocrinology
    • Animal Reproduction
    • Endocrinology

    Background:

    • Testosterone plays a role in reproductive cycles.
    • Understanding testosterone's impact on ovarian function is crucial for reproductive health.

    Purpose of the Study:

    • To investigate the effects of active immunization against testosterone on ovarian function and oestrous cycles in ewes.

    Main Methods:

    • Ewes were actively immunized against testosterone-conjugated bovine serum albumin (testosterone-3-BSA) or BSA alone.
    • Secretion rates of testosterone, oestradiol, and androstenedione were measured.
    • Ovarian morphology, ovulation rates, and steroid concentrations in plasma and follicular fluid were analyzed.

    Main Results:

    Related Experiment Videos

    • Immunization against testosterone disrupted oestrous cycles, causing anovulation or irregular ovulations.
    • Ovaries showed signs of over-stimulation with increased numbers of large follicles and corpora lutea.
    • Concentrations of androstenedione and oestradiol in ovarian venous plasma were significantly elevated in immunized ewes.

    Conclusions:

    • Active immunization against testosterone disrupts normal ovarian cycles and leads to ovarian over-stimulation in ewes.
    • Testosterone influences the regulation of ovarian activity and steroidogenesis.