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Related Experiment Videos

Apomorphine hypothermia: interaction with serotonergic agents

S K Kulkarni

    Polish Journal of Pharmacology and Pharmacy
    |January 1, 1980
    PubMed
    Summary
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    Apomorphine (APO) causes dose-dependent hypothermia in mice, involving different receptors at low and high doses. Fluoxetine reversed high-dose APO hypothermia, suggesting complex receptor interactions.

    Area of Science:

    • Neuropharmacology
    • Animal Models

    Background:

    • Apomorphine (APO) is a non-selective dopamine receptor agonist.
    • Understanding APO's hypothermic effects is crucial for its therapeutic applications and side effect management.

    Purpose of the Study:

    • To investigate the receptor mechanisms underlying apomorphine-induced hypothermia in mice.
    • To differentiate the effects of APO at low versus high doses.

    Main Methods:

    • Administered varying doses of apomorphine (0.25-16 mg/kg) to mice.
    • Utilized dopamine antagonists (haloperidol, clozapine), alpha-blockers (phenoxybenzamine), and serotonin-modulating agents (levopropranolol, cyproheptadine, fluoxetine) to assess receptor involvement.
    • Observed hypothermic responses and behavioral stereotypy.

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    Main Results:

    • Apomorphine induced a dose-dependent hypothermia.
    • Haloperidol antagonized low-dose APO-induced hypothermia.
    • Fluoxetine reversed high-dose APO-induced hypothermia but not low-dose effects.
    • Neither clozapine, phenoxybenzamine, levopropranolol, nor cyproheptadine significantly altered APO hypothermia.
    • Behavioral stereotypy was unaffected by fluoxetine.

    Conclusions:

    • Apomorphine-induced hypothermia in mice is mediated by distinct receptor systems at low and high doses.
    • High-dose hypothermia appears to involve interactions between multiple receptor types, including serotonergic pathways.
    • Low-dose hypothermia is primarily mediated by dopaminergic pathways sensitive to haloperidol.