Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased bleeding during liver resection in ethanol-intoxicated rats

S Bengmark, G Göransson, J Idvall

    Thrombosis and Haemostasis
    |July 15, 1980
    PubMed
    Summary

    Ethanol intoxication significantly increases bleeding and blood loss after liver resection in rats, despite unchanged coagulation times. This suggests impaired hemostasis in intoxicated patients undergoing liver surgery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Contaminated landslide runout deposits in rivers - Method for estimating long-term ecological risks.

    The Science of the total environment·2018
    Same author

    Peripheral leucocyte count variations in rectal cancer treatment.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2009
    Same author

    Local infusion of the nitric oxide donor Sin-1 after angioplasty. Effects on intimal hyperplasia in porcine coronary arteries.

    Acta radiologica (Stockholm, Sweden : 1987)·2003
    Same author

    [Influence of probiotics and fibre on the incidence of bacterial infections following major abdominal surgery - results of a prospective trial].

    Zeitschrift fur Gastroenterologie·2002
    Same author

    Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis.

    The British journal of surgery·2002
    Same author

    Differential roles of endogenous nitric oxide on neural regulation of basal exocrine pancreatic secretion in intact and denervated pancreas.

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2002

    Area of Science:

    • Surgical Research
    • Toxicology
    • Physiology

    Background:

    • Liver resection is a major surgery with potential bleeding complications.
    • Ethanol intoxication is common and may affect surgical outcomes.
    • Hemostasis is critical for managing bleeding during and after surgery.

    Purpose of the Study:

    • To investigate the impact of ethanol intoxication on hemostasis following liver resection in a rat model.
    • To determine if ethanol affects bleeding time, blood loss, and coagulation parameters post-liver resection.

    Main Methods:

    • Rats were subjected to liver resection under ethanol intoxication or control conditions.
    • Measurements included bleeding time, blood loss, hemoglobin, hematocrit, APTT, platelet count, and platelet aggregation.

    Related Experiment Videos

  • Cardiac output and regional blood flow (renal, hepatic artery, portal vein) were assessed.

    • Main Results:

    • Ethanol-intoxicated rats showed significantly increased bleeding time and blood loss post-resection.
    • Hemoglobin and hematocrit levels were reduced in intoxicated rats.
    • Platelet aggregation was slightly inhibited one hour after ethanol administration in non-operated animals.
    • Ethanol intoxication significantly altered cardiac output distribution, increasing renal and hepatic blood flow.

    Conclusions:

    • Ethanol intoxication impairs hemostasis after liver resection in rats, leading to increased blood loss.
    • The observed effects are likely due to mechanisms beyond simple alterations in coagulation parameters or pH.
    • These findings highlight potential risks for patients with ethanol intoxication undergoing liver surgery.