Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contractile function in chronic gradually developing subcoronary aortic stenosis

B A Carabello, R Mee, J J Collins

    The American Journal of Physiology
    |January 11, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Differentiable Material Point Method Framework for Shape Morphing.

    IEEE transactions on visualization and computer graphics·2025
    Same author

    Search for the Exclusive W Boson Hadronic Decays W^{±}→π^{±}γ, W^{±}→K^{±}γ and W^{±}→ρ^{±}γ with the ATLAS Detector.

    Physical review letters·2024
    Same author

    Determination of the Relative Sign of the Higgs Boson Couplings to W and Z Bosons Using WH Production via Vector-Boson Fusion with the ATLAS Detector.

    Physical review letters·2024
    Same author

    Statistical Combination of ATLAS Run 2 Searches for Charginos and Neutralinos at the LHC.

    Physical review letters·2024
    Same author

    Combination of Measurements of the Top Quark Mass from Data Collected by the ATLAS and CMS Experiments at sqrt[s]=7 and 8 TeV.

    Physical review letters·2024
    Same author

    Azimuthal Angle Correlations of Muons Produced via Heavy-Flavor Decays in 5.02 TeV Pb+Pb and pp Collisions with the ATLAS Detector.

    Physical review letters·2024
    Same journal

    Blood coagulation in fish.

    The American journal of physiology·2011
    Same journal

    Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

    The American journal of physiology·2010
    Same journal

    The inactivation of placental toxin by human serum.

    The American journal of physiology·2010
    Same journal

    Adrenal function following ovariectomy in the rat.

    The American journal of physiology·2010
    Same journal

    Capillary permeability; perfusion of frog and guinea pig hind limbs.

    The American journal of physiology·2010
    Same journal

    Evaluation of protective measures against sunburn.

    The American journal of physiology·2010
    See all related articles

    Gradually developing cardiac hypertrophy in dogs did not impair heart muscle function. This study suggests that chronic hypertrophy, unlike acute overload, maintains normal myocardial contractile performance.

    Area of Science:

    • Cardiovascular Physiology
    • Cardiac Hypertrophy Research

    Background:

    • Controversy exists regarding the functional status of hypertrophied cardiac muscle.
    • Previous animal studies often used acute pressure overload, potentially causing myocardial injury.
    • The impact of chronic, slow-developing hypertrophy on cardiac function remains less understood.

    Purpose of the Study:

    • To investigate if chronic, gradually developing cardiac hypertrophy is associated with normal myocardial function.
    • To develop and utilize an experimental model for slow-onset left ventricular hypertrophy in dogs.

    Main Methods:

    • Aortic banding was performed on puppies to gradually increase afterload as they grew.
    • Two groups were studied: early banding (group A) and late banding (control group B).

    Related Experiment Videos

  • Cardiac function was assessed by measuring ejection fraction, dP/dt, Vcf, and stroke work per gram of myocardium.

    • Main Results:

    • Group A animals exhibited moderate cardiac hypertrophy, indicated by an increased left ventricular weight to body weight ratio (5.3 +/- 0.24) compared to controls (3.9 +/- 0.14).
    • Key indicators of myocardial contractile performance, including ejection fraction, dP/dt, Vcf, and stroke work per gram of myocardium, were virtually identical between the hypertrophied and control groups.
    • The experimental model successfully induced moderate cardiac hypertrophy without acute myocardial injury.

    Conclusions:

    • Moderate cardiac hypertrophy that develops gradually, as induced by this model, is associated with normal myocardial contractile performance.
    • This finding challenges the notion that cardiac hypertrophy invariably leads to functional impairment.
    • The method of inducing hypertrophy is critical when assessing its functional consequences.