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Control of development by steady ionic currents

L F Jaffe

    Federation Proceedings
    |February 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Developing cells generate steady ionic currents that actively influence cell differentiation and growth. These bioelectric currents play crucial roles in processes from egg development to wound healing.

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    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Bioelectricity

    Background:

    • Developing cells generate steady ionic currents.
    • These currents arise from the separation of ion pumps and leaks across cell membranes.
    • Ionic currents are not mere byproducts but actively influence cellular processes.

    Purpose of the Study:

    • To explore the role of ionic currents in cellular development and differentiation.
    • To investigate how endogenous electric fields impact biological systems.
    • To provide evidence for the functional significance of bioelectric currents in various biological contexts.

    Main Methods:

    • Review and synthesis of existing evidence from diverse biological systems.
    • Analysis of ionic current generation and its effects in developing cells.

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  • Examination of experimental data on bioelectric phenomena in specific model organisms.

    • Main Results:

    • Ionic currents can self-amplify and induce localized growth (e.g., fucoid eggs).
    • Transcellular currents facilitate macromolecule transport (e.g., Cecropia follicles).
    • Endogenous voltage gradients direct cell growth and regeneration (e.g., amphibian limbs, frog embryos, mammalian skin).

    Conclusions:

    • Steady ionic currents are critical regulators of cell differentiation and development.
    • Bioelectric fields act as signaling mechanisms guiding cellular behavior and tissue organization.
    • Understanding these currents offers insights into developmental processes and regenerative medicine.