The lactogenic response of mouse mammary explants to mose prolactin and growth hormone

The lactogenic response of mouse mammary explants to mouse prolactin (mPRL) and mouse growth hormone (mGH) was studied. Mouse mammary explants were cultured, in a defined medium, in the presence of varying concentrations of either mPRL or mGH and the rate of 3H amino acid incorporation into casein was measured. The lactogenic activity of mPRL was compared with that of ovine prolactin (oPRL) and found to be directly comparable. MGH, when compared to oPRL, was found to be less active in stimulating casein synthesis.