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Potassium current during the pacemaker depolarization in rabbit sinoatrial node cell

K Yanagihara, H Irisawa

Pflugers Archiv : European Journal of Physiology

|December 1, 1980

Summary

Potassium current is unlikely to be essential for sinoatrial node pacemaker potential. Slow inward current and hyperpolarization-activated current are more critical for spontaneous action potential generation in the heart's natural pacemaker.

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Area of Science:

Cardiology
Electrophysiology
Cellular Biology

Background:

The sinoatrial (S-A) node acts as the heart's natural pacemaker.
Understanding the ionic currents responsible for pacemaker potential is crucial for cardiac electrophysiology.

Purpose of the Study:

To investigate the role of the delayed outward potassium current (iK) in generating the pacemaker potential of the rabbit S-A node.
To determine the relative contributions of different ionic currents to S-A node automaticity.

Main Methods:

Voltage clamp experiments on rabbit S-A node cells.
Application of 5 mM Ba2+ to block delayed outward currents.
Computational modeling of potassium current kinetics (iK).

Main Results:

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Barium ions (Ba2+) significantly reduced the delayed outward current in the S-A node.
Slow inward current and hyperpolarization-activated current remained unaffected by Ba2+.
S-A node cells generated spontaneous action potentials without time-dependent potassium current when hyperpolarized.

Conclusions:

The time-dependent potassium current (iK) is unlikely to play an essential role in S-A node pacemaker potential generation.
The gradual decay of potassium conductance has a minor role in pacemaker depolarization compared to the slow inward current.