Tissue adhesive Histoacryl (2-cyano-butyl-acrylate) in experimental middle ear surgery

The tissue adhesive Histoacryl (2-cyano-butylacrylate) was experimentally applied to the stapes region of nine middle ears of baboons. Stapes footplate, labyrinth, and middle ear did not show any damage or injury due to the adhesive application. Only minor inflammatory reactions were observed to surround the adhesive bubbles. Histoacryl is considered safe for use in human ear surgery.