Dioxychlorane: a challenge to the correlation of anesthetic potency and lipid solubility

Dioxychlorane is a five-membered cyclic halogenated diether which has been reported to be anesthetic at an inspired concentration of 0.3% atm and to have an oil/gas partition coefficient to 260 to 275. These values suggested that dioxychlorane might represent a significant deviation from the correlation of anesthetic potency with lipid solubility. However, the results of this study did not confirm the above data: MAC in four dogs was 0.11 +/- 0.02 (SE) % atm, and the oil/gas partition coefficient was 1,286 +/- 44. Dioxychlorane appears not to be an exception to the correlation of anesthetic potency with lipid solubility.