Effect of dihydroxydibutylether (DHBE) on bile flow and composition in rats with ethynylestradiol-induced cholestasis

Administration of dihydroxydibutylether (DHBE, Dis-Cinil) to rats with ethynylestradiol(EE)-induced cholestasis provoked an increase in bile flow and output of bile acids and phospholipids. Since EE-induced cholestasis is related to the condition observed in humans, a clinical trial of DHBE in cholestatic syndromes seems worthwhile.