Hemodynamic effects of the new vasodilator drug Bay k 5552 in man

The hemodynamic effects of the new vasodilator drug isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylate (nisoldipine, Bay k 5552) were observed in 9 patients undergoing cardiac catheterization. The drug was administered i.v. in a dose of 1.5 microgram/kg body weight. Within 1 min after injection aortic pressure decreased by 11.5 +/- 6.4%, cardiac index increased by 23.1 +/- 13.5%, and heart rate accelerated by 18.3 +/- 10.1% of control value. Calculated total peripheral resistance was reduced by 28.2 +/- 10.1%. The whole low pressure system as well as the dp/dt max remained unaffected by the drug. The stroke volume index showed a slight and insignificant increase. Thus, Bay k 5552 represents a fast and power fully acting vasodilating substance with its actions being restricted mainly to the peripheral vasculature.