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Related Experiment Videos

Scrapie-associated particles in postsynaptic processes. Further ultrastructural studies

J R Baringer, S B Prusiner, J S Wong

    Journal of Neuropathology and Experimental Neurology
    |May 1, 1981
    PubMed
    Summary

    Electron microscopy revealed that tubular densities in scrapie-infected mice are not true tubular structures. Instead, these appearances are caused by the overlapping of tightly aggregated spherical particles.

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    Area of Science:

    • Neuroscience
    • Pathology
    • Microscopy

    Background:

    • Clinical scrapie in mice presents with both tubular and spherical densities in postsynaptic processes.
    • The precise ultrastructural nature of these densities has been a subject of investigation.

    Purpose of the Study:

    • To elucidate the true morphology of tubular densities observed in postsynaptic processes of mice with clinical scrapie.
    • To differentiate between genuine tubular structures and artifacts arising from particle aggregation.

    Main Methods:

    • High-resolution electron microscopic examination was employed.
    • Specimen tilting through large angles was utilized to analyze the three-dimensional structure of the densities.

    Main Results:

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  • Analysis of tilted specimens demonstrated that the observed tubular appearances are not indicative of true tubular structures.
  • In all analyzable instances, the tubular morphology resulted from the overlapping of tightly aggregated spherical particles.

    • Conclusions:

    • The study concludes that tubular densities in scrapie-infected mice are an artifact of spherical particle aggregation.
    • This finding clarifies the ultrastructure of pathological changes in scrapie, emphasizing the role of spherical particle organization.