[Effect of nifedipine on the ventricular diastolic stimulation threshold of the human heart]

The Ca-antagonist 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarbonic acid dimethylester (nifedipine) does not lead to an elevation of human myocardial stimulus-threshold in contrast to another injectable Ca-antagonist verapamil. There was no increase or decrease in bradycardiac arrhythmia in this study. Therefore beta-blockers and antiarrhythmic drugs given simultaneously will not have intolerable pharmacodynamic interaction with nifedipine in bathmotropic and bradycardiac arrhythmia.