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Related Experiment Videos

Changes in 2,3-Diphosphoglycerate (2,3-DPG) after exercise

H D Meen, P H Holter, H E Refsum

    European Journal of Applied Physiology and Occupational Physiology
    |January 1, 1981
    PubMed
    Summary
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    Heavy exercise causes a slow but significant increase in erythrocyte 2,3-DPG levels, reaching a new peak 30-45 minutes post-exertion. This finding clarifies previous conflicting results on exercise and 2,3-DPG.

    Area of Science:

    • Exercise Physiology
    • Biochemistry
    • Hematology

    Background:

    • Conflicting previous research exists on how physical exercise impacts erythrocyte 2,3-DPG levels.
    • The recovery phase after exercise may significantly alter factors governing 2,3-DPG metabolism.

    Purpose of the Study:

    • To investigate the prolonged time course of erythrocyte 2,3-DPG changes after different durations of heavy exercise.
    • To clarify the relationship between exercise intensity, recovery, and 2,3-DPG levels.

    Main Methods:

    • Five healthy males underwent three exercise protocols on separate days: 6-min, 6-min + 6-min (with 1-hr rest), and 60-min exercise.
    • Erythrocyte 2,3-DPG levels were measured at multiple time points up to 4 hours post-exercise.
    • Exercise protocols varied in intensity, with shorter bouts inducing lactate acidosis and the 60-min bout being aerobic.

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    Main Results:

    • Short exercise bouts (6-min, 6+6-min) initially showed no change or a slight decrease in 2,3-DPG, followed by an 8-12% increase by 30-45 minutes post-exercise (P < 0.001).
    • The 60-min aerobic exercise resulted in a 10% increase in 2,3-DPG by 45 minutes post-exercise (P < 0.001).
    • Across all protocols, 2,3-DPG levels remained elevated for at least 4 hours post-exercise.

    Conclusions:

    • Heavy physical exercise induces a consistent, delayed increase in erythrocyte 2,3-DPG.
    • The findings suggest a specific metabolic adaptation in erythrocytes following strenuous physical activity.
    • A prolonged elevation of 2,3-DPG post-exercise may have implications for oxygen transport and delivery.