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[Kinetic parameters of D(+)-glucose in epileptic children and under anticonvulsive therapy (author's transl)]
Insights
Children with recurrent seizures have altered glucose metabolism. Anticonvulsant therapy normalized glucose kinetic parameters, indicating improved D-glucose processing in pediatric epilepsy patients.
Area of Science:
- Pediatric Neurology
- Clinical Biochemistry
- Pharmacology
Context:
- Recurrent convulsive disorders in children aged 5-14 years.
- Assessment of D-glucose kinetic parameters in pediatric epilepsy.
- Comparison between pre-treatment and post-treatment metabolic states.
Purpose:
- To investigate the impact of anticonvulsant therapy on D-glucose kinetic parameters in children with recurrent convulsive disorders.
- To determine if drug treatment normalizes altered glucose metabolism associated with epilepsy.
- To explore the relationship between glucose metabolism, seizure activity, and electroencephalogram (EEG) abnormalities.
Summary:
- Kinetic parameters of D-glucose were analyzed in 17 children (5-14 years) with recurrent convulsive disorders before and after anticonvulsant treatment.
- Pre-treatment, a significantly shorter glucose elimination half-life (1.5 ± 5.4 min) and decreased glucose pool were observed.
- Post-treatment, the elimination half-life normalized (19.6 ± 4.9 min), and the glucose pool increased.
- Long-term treatment showed increased glucose metabolization rates during seizures or EEG abnormalities.
- Neither treatment duration nor drug type affected glucose kinetic parameters.
Impact:
- Provides insights into the metabolic disturbances in pediatric epilepsy.
- Highlights the normalizing effect of anticonvulsant therapy on glucose kinetics.
- Suggests glucose metabolism as a potential biomarker or therapeutic target in pediatric seizure disorders.
- Informs clinical management by demonstrating the efficacy of treatment on metabolic parameters.
Abstract:
In 17 Children 5-14 years old, suffering from recurrent convulsive disorders the kinetic parameters of D(+)-glucose were determined before and after treatment. 20 children treated with different anticonvulsants for many years were included in the study, 11 children served as control group. The elimination half-life of glucose is significantly shorter (1.5 plus or minus 5,4 min) before treatment. After sufficient drug therapy the elimination half-life becomes normal (19.6 plus or minus 4.9 min). The glucose pool which is decreased before treatment normalizes when drugs are given. During long term treatment the glucose transfer (metabolisation rate) is increased when convulsions occur or abnormalities of the EEG are observed. Neither the duration of the treatment nor the kind of drugs seem to influence the kinetic parameters of glucose.