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Related Experiment Videos

Tumor shedding and coagulation

H F Dvorak, S C Quay, N S Orenstein

    Science (New York, N.Y.)
    |May 22, 1981
    PubMed
    Summary
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    Cancer cells release tiny membrane vesicles that activate blood clotting. This procoagulant activity may explain fibrin deposition seen in many cancers in animals and humans.

    Area of Science:

    • Oncology
    • Hematology
    • Cell Biology

    Background:

    • Malignancies in animals and humans are often associated with blood clotting and fibrin deposition.
    • The precise mechanisms driving this procoagulant activity in cancer remain incompletely understood.

    Purpose of the Study:

    • To investigate the role of plasma membrane vesicles shed by syngeneic carcinomas in activating the blood clotting system.
    • To determine if these shed vesicles can account for the fibrin deposition observed in malignancy.

    Main Methods:

    • Culturing three syngeneic carcinomas in vitro.
    • Analyzing vesicles shed from tumors grown in vivo (ascites form).
    • Assessing the procoagulant activity of the shed plasma membrane vesicles.

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    Main Results:

    • Three syngeneic carcinomas, from two different species, were observed to shed plasma membrane vesicles.
    • These shed vesicles exhibited significant procoagulant activity.
    • The procoagulant activity of the vesicles was sufficient to activate the clotting system.

    Conclusions:

    • Plasma membrane vesicles shed by certain cancer cells possess procoagulant activity.
    • This activity is a likely mechanism for the observed fibrin deposition in malignancy.
    • Understanding this process may offer new insights into cancer-associated thrombosis.