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Abnormal fibrils from scrapie-infected brain

P A Merz, R A Somerville, H M Wisniewski

    Acta Neuropathologica
    |January 1, 1981
    PubMed
    Summary

    Abnormal fibrillary structures called scrapie-associated fibrils (SAF) were found in scrapie-affected animal brains. These fibrils, distinct from normal brain components, resemble amyloid structures.

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    Area of Science:

    • Neuroscience
    • Biochemistry
    • Pathology

    Background:

    • Scrapie is a transmissible spongiform encephalopathy affecting animals.
    • Abnormal protein aggregates are implicated in neurodegenerative diseases.

    Purpose of the Study:

    • To characterize the morphology of abnormal fibrillary structures in scrapie-affected brains.

    Main Methods:

    • Negative stain electron microscopy was used to examine brain subfractions.
    • Morphological comparison with normal brain fibrils and amyloid.

    Main Results:

    • Scrapie-associated fibrils (SAF) were consistently observed in scrapie-affected brains.
    • SAF are composed of two or four filaments and differ from microtubules, neurofilaments, glial filaments, and F-actin.
    • SAF exhibit morphological similarities to amyloid.

    Conclusions:

    • SAF represent a distinct fibrillary structure associated with scrapie.
    • The morphology of SAF suggests a potential link to amyloid formation in prion diseases.

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