Effects of AR-L 115 BS on hemodynamics, myocardial oxygen consumption and cardiac pumping efficiency

The effects of 2-[(2-methoxy-4-methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) on hemodynamics, myocardial oxygen consumption and cardiac pumping efficiency were tested on closed-chest dogs in cardiac catheterization technique. Doses in the range of 0.1 up to 4.0 mg/kg b. w. were injected i.v. A therapeutical dose is to be expected in the range of 1.0 mg/kg b. w., showing a distinct positive inotropic effect and reducing endsystolic volume without increase of heart rate and myocardial oxygen consumption.