A double blind crossover tolerance study of AR-L 115 BS in health volunteers

In a double blind crossover study in 20 healthy volunteers, aged between 19 and 32 years, 2-[(2-methoxy-4-methyl-sulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) 100 mg q.i.d. for 1 week was compared with placebo. No drug effect was found on blood pressure (lying and standing, systolic and diastolic), heart rate, full blood count, blood chemistry (including liver functions), urinalysis; no side-effects were reported.