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Simultaneous treatment with cisplatin and radiation therapy for advanced solid tumors: a pilot study
Cancer Treatment Reports
|March 1, 1981
Summary
This study found that weekly cisplatin chemotherapy combined with radiation therapy showed moderate toxicity and high efficacy in treating metastatic solid tumors. Most irradiated lesions responded, particularly in melanoma patients, suggesting further evaluation for unresectable tumors.
Area of Science:
- Oncology
- Medical Oncology
- Radiation Oncology
Background:
- Metastatic solid tumors present significant treatment challenges.
- Combined modality treatments are explored to improve patient outcomes.
Purpose of the Study:
- To evaluate the toxicity and efficacy of simultaneous cisplatin chemotherapy and palliative radiation therapy.
- To assess response rates and toxicities in patients with metastatic solid tumors.
Main Methods:
- 13 patients with metastatic solid tumors received weekly cisplatin (20-50 mg/m2) during palliative radiation therapy.
- Various radiation dose-fraction schedules were employed.
- Toxic effects and lesion response were monitored.
Main Results:
- 91% of irradiated lesions showed at least a 50% reduction in diameter.
- Moderate toxicities included emesis, transient BUN elevation, myelosuppression, and radiation reactions.
- Complete regression was observed in 4/6 metastatic melanoma patients; responses seen in mesothelioma, bladder, head and neck, and lung cancers.
Conclusions:
- Weekly cisplatin during radiotherapy is a viable treatment option with manageable toxicity.
- The combination demonstrates significant efficacy, particularly in cisplatin-sensitive tumors.
- Further investigation is warranted, especially for unresectable tumors responsive to cisplatin alone.