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Total and specific IgE (RAST) in atopic twins
Clinical Allergy
|March 1, 1981
Summary
Genetic factors influence atopy tendency, but environmental factors shape its specificity. This twin study found higher atopy concordance in monozygotic twins, suggesting a genetic predisposition for immunoglobulin E (IgE) production.
Area of Science:
- Immunology
- Genetics
- Allergy Research
Background:
- Atopy, a predisposition to allergic diseases, has a known genetic component.
- Understanding the interplay between genetics and environment in atopy is crucial for disease management.
Purpose of the Study:
- To investigate the genetic and environmental influences on atopy and immunoglobulin E (IgE) levels in twins.
- To compare concordance rates of atopy and IgE levels between monozygotic (MZ) and dizygotic (DZ) twins.
Main Methods:
- Skin prick tests, Radioallergosorbent tests (RAST), and serum IgE level determinations were performed on 50 twin sets (30 MZ, 20 DZ).
- Concordance rates for atopy and correlations in IgE levels were analyzed between MZ and DZ pairs.
Main Results:
- Atopy concordance was significantly higher in MZ twins (56.7%) compared to DZ twins (20%).
- While mean IgE level differences were not significant between MZ and DZ twins, IgE levels showed closer correlation within MZ pairs.
- Specific reagin production (RAST, skin tests) concordance did not differ significantly between MZ and DZ sets.
Conclusions:
- The tendency for immunoglobulin E (IgE) production appears to be genetically determined.
- The specificity of IgE responses in atopy is predominantly influenced by environmental factors.