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Depressed neutrophil chemotaxis in infants with cow's milk and/or soy protein intolerance
Insights
Infants with active cow's milk or soy protein intolerance show impaired neutrophil chemotaxis and increased random migration. These neutrophil functions normalize upon recovery, suggesting a reversible effect of food protein intolerance on immune cell behavior.
Area of Science:
- Immunology
- Pediatrics
- Gastroenterology
Background:
- Cow's milk and soy protein intolerance are common in infants.
- Immune system dysregulation may play a role in food protein intolerance.
Purpose of the Study:
- To investigate neutrophil function in infants with active food protein intolerance.
- To assess if neutrophil function changes with clinical recovery.
Main Methods:
- Studied neutrophil chemotaxis and random migration in 11 infants with active intolerance.
- Compared results to 15 age-matched controls and 4 recovered infants.
- Utilized established methods for assessing neutrophil motility.
Main Results:
- Infants with active intolerance demonstrated significantly depressed neutrophil chemotaxis.
- Enhanced random migration of neutrophils was observed in actively intolerant infants.
- Neutrophil function normalized in infants after clinical recovery.
Conclusions:
- Active cow's milk and/or soy protein intolerance is associated with altered neutrophil migration patterns.
- These alterations in neutrophil function are reversible with clinical improvement.
- Neutrophil dysfunction may contribute to the pathophysiology of infant food protein intolerance.
Abstract:
Neutrophil chemotaxis and random migration were studied in 11 infants with active cow's milk and/or soy protein intolerance and in an additional four infants following clinical recovery. Results were compared to 15 age-matched control subjects. Infants with active intolerance exhibited depressed chemotaxis and enhanced random migration. The four recovered infants had values similar to those of control subjects.