[Effect of tinofedrine on oxygen, glucose and lactate metabolism in dogs and rats]

(+)-(R)-alpha(S)-1-[(3-3-Di-3-thienylallyl) amino]-ethyl-benzyl alcohol hydrochloride (tinofedrine hydrochloride) is a newly synthetized hemodynamic and cerebrally active substance. The results were obtained with dogs by synchronous measurement of vertebral and local cerebral blood flow, and assessment of O2, glucose and lactate metabolisms, In rats the cerebral glucose uptake index was taken as a scale for the glucose extraction. With dogs i.v. administration of tinofedrine causes, besides a marked and long-lasting rise of the cerebral blood flow, a strong increase of the glucose extraction. Compared to glucose up-take, the O2 increase is much smaller and lactate delivery unchanged. This indicates, besides a metabolic degradation, the utilization of the obtained glucose as a depot substate. Also in rats tinofedrine causes a significant glucose extraction, expressed as a remarkable rise of the brain uptake index.