Hypolipidemic effect of L-form S-methylmethionine sulfonium chloride in man

The effect of L-form S-methylmethionine sulfonium chloride (L-MMSC) was studied in 26 patients with hypercholesterolemia during the oral administration period for 8 weeks (daily dose 1500 mg). The oral administration of L-MMSC resulted in the statistically significant decrease of serum total cholesterol (9.7%, P less than 0.001), but not of serum triglycerides. In addition, the statistically significant increases in serum high-density lipoprotein-cholesterol (HDL-cholesterol) and in the ratios of HDL-cholesterol/(total cholesterol) -- (HDL-cholesterol) and HDL-cholesterol/(total cholesterol) + (triglycerides) were observed by the administration of L-MMSC. The therapeutic effects in in-patients were more remarkable than those in outpatients.