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Ipsi-and contralateral changes in rabbit soleus myosins by cross-reinnervation
Cross reinnervation of soleus muscle in the adult rabbit induces changes in myosin light chain and isomyosin patterns. The transformation of the light chain pattern consists of a decrease in LC1's and LC2, and an induction of the three fast type myosin light chains. The transition in the isomyosin pattern consists of a decrease of the slow type isomyosin SM and an induction of fast type isomyosins FM1, FM2, and FM3 normally seen in fast-twitch rabbit muscle. An additional isomyosin of intermediate electrophoretic mobility, which resembles isomyosin 4 of rat muscle, is induced. These changes are not restricted to the cross-reinnervated soleus muscle but are also seen, although to a lesser extent, in the contralateral soleus muscle. It is suggested that the altered afferent activity brought about by cross-reinnervation, is neurally transmitted to the opposite side and leads to a change in efferent activity to the contralateral muscle.
Cross reinnervation of soleus muscle in the adult rabbit induces changes in myosin light chain and isomyosin patterns. The transformation of the light chain pattern consists of a decrease in LC1's and LC2, and an induction of the three fast type myosin light chains. The transition in the isomyosin pattern consists of a decrease of the slow type isomyosin SM and an induction of fast type isomyosins FM1, FM2, and FM3 normally seen in fast-twitch rabbit muscle. An additional isomyosin of intermediate electrophoretic mobility, which resembles isomyosin 4 of rat muscle, is induced. These changes are not restricted to the cross-reinnervated soleus muscle but are also seen, although to a lesser extent, in the contralateral soleus muscle. It is suggested that the altered afferent activity brought about by cross-reinnervation, is neurally transmitted to the opposite side and leads to a change in efferent activity to the contralateral muscle.