[Emotionally positive reactions in the process of development of diazepam dependence]

Rats with lateral hypothalamic electrodes were treated with diazepam in doses of 10--20 mg/kd during 10 days. Part of the animals showed tolerance to the inhibitory effect of the drug. Within the drug administration period depression of the self-stimulation response was observed under 24-hour abstinence. After diazepam withdrawal two forms of abstinent changes were noted--inhibition and facilitation. The effects of diazepam were modulated by opiate receptors' blockade with naloxon.