[Correlation between the stress-protective and vegetotropic action of mebikar]

Mebicar, a tranquilizer of the group of tetra-N-alkyl bicyclic bis-ureas, under acute emotional stress in cats (confrontation with a dog), simultaneously with tranquilizing effect on behavior also improves central baroreflex control and reduces hypertensive reaction of the arterial pressure. In rats, it normalizes disorders of individual and intraspecies behavior induced by the stress of a long-term social isolation. It decreases the degree of ulcer injury of the stomach during the immobilization stress.