Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune complexes in syphilis sera

G Wozniczko-Orlowska, F Milgrom

    Journal of Immunology (Baltimore, Md. : 1950)
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Circulating immune complexes (CIC) were found in 20.7% of syphilis sera. Cardiolipin and syphiloma extract differentially dispersed these complexes, suggesting distinct compositions in syphilis and other diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Immunologic injury of renal homografts.

    The Journal of experimental medicine·2009
    Same author

    My relations with five generations of immunologists.

    Transplantation proceedings·1999
    Same author

    Humoral transplantation antibodies.

    Transplantation proceedings·1999
    Same author

    My association with Ludwik Hirszfeld, Wrocław 1945-1954.

    Archivum immunologiae et therapiae experimentalis·1998
    Same author

    Tissue suspension agglutination: a simple method to screen species-specific and organ-specific reactions.

    International archives of allergy and immunology·1997
    Same author

    "Heterophile" antigen in sera of human recipients of renal allografts.

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·1996

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Serology

    Background:

    • Syphilis diagnosis relies on serological tests like VDRL and FTA-ABS.
    • Circulating immune complexes (CIC) are implicated in various autoimmune and infectious diseases.
    • Understanding CIC composition is crucial for disease pathogenesis and treatment.

    Purpose of the Study:

    • To investigate the presence and characteristics of CIC in syphilis patients.
    • To examine the differential dispersion of CIC by cardiolipin and syphilis extract.
    • To explore potential differences in CIC composition across various conditions.

    Main Methods:

    • Studied 449 syphilis sera positive for VDRL and FTA-ABS.
    • Detected CIC using the anti-antibody (AA) neutralization test.

    Related Experiment Videos

  • Assessed CIC dispersion with cardiolipin and rabbit testicular syphiloma extract.
  • Examined CIC in lepromatous leprosy and SLE sera for comparison.

    • Main Results:

    • Demonstrable CIC were present in 93 (20.7%) syphilis sera.
    • Cardiolipin dispersed CIC in 16 of 40 (40%) sera; syphiloma extract dispersed CIC in 16 of 32 (50%) sera.
    • Dispersion was specific: CIC dispersed by cardiolipin were not affected by syphiloma extract, and vice versa.
    • Cardiolipin affected 2 of 9 SLE CIC-containing sera but none of 27 lepromatous leprosy CIC-containing sera.
    • Cardiolipin-anti-cardiolipin and syphiloma extract-anti-treponemal antibody complexes were observed.

    Conclusions:

    • Syphilis patients frequently exhibit CIC, detectable by AA neutralization.
    • Cardiolipin and syphilis extract exhibit specific, non-overlapping abilities to disperse CIC.
    • These findings suggest distinct CIC compositions in syphilis, potentially differing from those in SLE and leprosy.
    • The study highlights the utility of differential dispersion assays for characterizing CIC in infectious and autoimmune diseases.