[Metaplastic and proliferative processes of the bladder mucosa in elderly patients (author's transl)]

The frequency of 20 morphological findings in bladders fixed shortly after death obtained at post mortem examination from an unselected nonurological series of 70 patients with a median age of 74 years, we studied by evaluation of 12 600 histological data. Squamous metaplasia was found in 27.8% of male and 82.2% of female subjects predominantly at the bladder neck and floor. Squamous metaplasia with different structures at the posterior and lateral wall showed a preponderance in the male subjects. Brunn's nests were observed in 88.9% of male and 88.2% of female patients, sometimes as "Brunn's nests in situ". Focal urothelial hyperplasia was seen in 41.7% of male and 38.2% of female, "labile epithelium" in 13.9% of male and 29.4+ female, micropapillomas in 13.9% male and 11.8% female patients. One male subject (72 years old) had an urothelial carcinoma measuring 1.2 cm (G-2-pT1) which was not recognised clinically.