Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Megakaryocytes in renal glomeruli

W L Broghamer, B Weakley-Jones

    American Journal of Clinical Pathology
    |August 1, 1981
    PubMed
    Summary

    Autopsy findings reveal significantly increased megakaryocytes in renal glomeruli, suggesting a systemic event. These changes often correlated with megakaryocyte increases in pulmonary circulation and bone marrow.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Colchicine poisoning: case report of two homicides.

    The American journal of forensic medicine and pathology·2001
    Same author

    Primary small cell undifferentiated carcinoma of the rectum associated with ulcerative colitis.

    Southern medical journal·1996
    Same author

    Unnatural deaths in nursing home patients.

    Journal of forensic sciences·1992
    Same author

    Cytohistologic correlation of urothelial lesions secondary to photodynamic therapy.

    Acta cytologica·1989
    Same author

    The forensic pathologist and the determination of driver versus passenger in motor vehicle collisions. The need to examine injury mechanisms, occupant kinematics, vehicle dynamics, and trace evidence.

    The American journal of forensic medicine and pathology·1989
    Same author

    Multiple adenocarcinomas of the colon and rectum. An analysis of incidences and current trends.

    Diseases of the colon and rectum·1988

    Area of Science:

    • Nephrology
    • Hematology
    • Pathology

    Background:

    • Megakaryocytes are crucial for platelet production.
    • Peripheral vascular megakaryocytosis can occur terminally.
    • Renal involvement in megakaryocyte distribution is not fully understood.

    Purpose of the Study:

    • To investigate the presence and significance of megakaryocytes in the renal glomerular capillary network.
    • To correlate renal megakaryocyte findings with other vascular beds and bone marrow.
    • To identify potential factors influencing renal megakaryocyte distribution.

    Main Methods:

    • Retrospective autopsy study of 118 cases.
    • Histological examination of renal, pulmonary, and bone marrow tissues.
    • Statistical analysis to determine significance (P < 0.001).

    Main Results:

    • Significant increase in renal glomerular megakaryocytes observed in 27 cases (P < 0.001).
    • Renal megakaryocyte increases generally corresponded with pulmonary microcirculation and bone marrow findings.
    • An exception was noted in patients with coagulopathy but without sepsis.

    Conclusions:

    • Increased renal glomerular megakaryocytes indicate a potential systemic megakaryocyte trafficking or release.
    • The findings suggest a link between terminal conditions, megakaryocyte distribution, and renal pathology.
    • Coagulopathy may influence the pattern of megakaryocyte distribution in the absence of sepsis.

    Related Experiment Videos