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A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
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Published on: August 7, 2017

Megakaryocytes in renal glomeruli

W L Broghamer, B Weakley-Jones

    American Journal of Clinical Pathology
    |August 1, 1981
    PubMed

    Insights

    Autopsy findings reveal significantly increased megakaryocytes in renal glomeruli, suggesting a systemic event. These changes often correlated with megakaryocyte increases in pulmonary circulation and bone marrow.

    Area of Science:

    • Nephrology
    • Hematology
    • Pathology

    Background:

    • Megakaryocytes are crucial for platelet production.
    • Peripheral vascular megakaryocytosis can occur terminally.
    • Renal involvement in megakaryocyte distribution is not fully understood.

    Purpose of the Study:

    • To investigate the presence and significance of megakaryocytes in the renal glomerular capillary network.
    • To correlate renal megakaryocyte findings with other vascular beds and bone marrow.
    • To identify potential factors influencing renal megakaryocyte distribution.

    Main Methods:

    • Retrospective autopsy study of 118 cases.
    • Histological examination of renal, pulmonary, and bone marrow tissues.
    • Statistical analysis to determine significance (P < 0.001).

    Main Results:

    • Significant increase in renal glomerular megakaryocytes observed in 27 cases (P < 0.001).
    • Renal megakaryocyte increases generally corresponded with pulmonary microcirculation and bone marrow findings.
    • An exception was noted in patients with coagulopathy but without sepsis.

    Conclusions:

    • Increased renal glomerular megakaryocytes indicate a potential systemic megakaryocyte trafficking or release.
    • The findings suggest a link between terminal conditions, megakaryocyte distribution, and renal pathology.
    • Coagulopathy may influence the pattern of megakaryocyte distribution in the absence of sepsis.

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