Penetration of parenteral cefuroxime into the human aqueous humor

Concentrations of (6R-[6 alpha,7 beta(Z)])-3-([(amino-carbonyl)oxy]metyl)-7-([2-furanyl(methoxyimino)-acethyl] amino)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carbonic acid (cefuroxime) were studied in blood and aqueous humor of 25 patients after various parenteral doses. lows: 1 h after a single 2 g i.v. dose; 1 h after the second of 2 1.v. doses of 2 g at an interval of 3 h; 6 h after a 2-g i.v. dose; 1 h after a 1.5-g i.m. dose; 1 h after the second of 2 i.m. doses of 1.5 g at an interval of 3 h. The highest levels of cefuroxime in blood (18.1 +/- 2.79 micrograms/ml) and in aqueous humor (4.1 +/- 1.98 micrograms/ml) were reached 1 h after the second administration of a 1.5-g i.m. dose.