Related Experiment Videos
Amphetamine behavioral toxicity: rotational behavior after chronic intrastriatal infusion
Biological Psychiatry
|May 1, 1981
Summary
This study investigated d-amphetamine tolerance in rats, finding that continuous high-dose exposure led to tolerance, not reverse tolerance. This suggests a potential mechanism for amphetamine-induced psychosis in humans.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- The phenomenon of behavioral
- reverse tolerance
- to d-amphetamine is not well-established for high-dose, sustained exposures relevant to human toxicity.
- Amphetamine psychosis is a significant concern in clinical settings.
Purpose of the Study:
- To investigate the development of tolerance to d-amphetamine following chronic, high-dose, unilateral infusion into the rat caudate-putamen.
- To assess behavioral responses to d-amphetamine after this novel pharmacologic intervention.
Main Methods:
- Continuous chronic unilateral infusion of high-dose d-amphetamine into the caudate-putamen of rats.
- Assessment of circling behavior in response to subsequent d-amphetamine injections and apomorphine-induced rotation.
Main Results:
- Rats pretreated with continuous d-amphetamine infusion showed ipsilateral circling in response to d-amphetamine injections, indicating tolerance development.
- Minimal apomorphine-induced rotation was observed, suggesting altered nigrostriatal dopamine activity.
Conclusions:
- Chronic, high-dose d-amphetamine administration into the caudate-putamen induces tolerance to its behavioral effects.
- A functional imbalance in nigrostriatal dopamine activity, potentially due to dopamine depletion, may underlie these observed changes.