Related Experiment Video
Updated: Aug 17, 2026

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection
Published on: March 28, 2012
Potentiating effects of cisplatin and ethacrynic acid in ototoxicity
Abstract:
Seven milligrams per kilogram of body weight of cisplatin and 50 mg/kg of body weight of ethacrynic acid were given intravenously to guinea pigs. The threshold for Preyer's reflex, the cochlear microphonics (CM), and the endocochlear dc potential (EP) were measured during a four-day period after the injection. The changes in Preyer's reflex audiometry and the CM were more severe than that of the EP. These changes are greater than those that occur with the administration of each agent independently. The ototoxic interaction seemingly has a greater effect on the hair cells than on the stria vascularis. Baseline and periodic audiometry should be performed when both of these drugs are administered clinically.
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
EDTA: Chemistry and Properties
EDTA: Auxiliary Complexing Reagents
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Antifungal Agents
Cytotoxic Edema: Pathophysiology

