[Possible discrepancy between behavioral adequacy and motor automatisms in cats with phenamine-induced stereotypy]

Experiments in cats were made to study the effect of the increasing doses of the neuroleptics haloperidol and clozapin as well as those of metoclopramide with weak antipsychotic properties on various characteristics of amphetamine-induced stereotypy. Haloperidol was shown to return the animals' behavior adequacy to normal and to concurrently eliminate the motor automatisms. Clozapin produced an earlier recovery of the psychoemotional state, exerting a less powerful effect of motor manifestation of stereotypy. On the contrary, metoclopramide eliminated motor disorders more readily but did not return the behavior adequacy to normal. The reason for dissociation of both the characteristics of stereotypy may lie in dissimilar participation in it of different parts of the caudate nucleus or in different implications of the caudate and extracaudate mechanisms.