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Circulating reverse triiodothyronine in humans during exercise

B N Premachandra, W W Winder, R Hickson

    European Journal of Applied Physiology and Occupational Physiology
    |January 1, 1981
    PubMed
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    Strenuous swimming and moderate exercise minimally impact thyroid hormone levels, showing no shift in metabolic pathways. Exercise did not divert thyroxine (T4) monodeiodination from T3 to rT3 production.

    Area of Science:

    • Endocrinology
    • Exercise Physiology
    • Metabolic Studies

    Background:

    • Thyroid hormones, including thyroxine (T4), triiodothyronine (T3), and reverse triiodothyronine (rT3), play crucial roles in regulating metabolism.
    • Understanding how metabolic activity, such as exercise, affects thyroid hormone pathways is important for sports science and clinical practice.

    Purpose of the Study:

    • To investigate the impact of acute exercise on circulating thyroid hormone levels.
    • To determine if increased metabolic activity during exercise alters the peripheral monodeiodination pathway of T4.

    Main Methods:

    • Measurements of T4, T3, rT3, blood lactate, and glucose in 12 trained subjects before and after swimming 0.18 or 0.9 km.
    • Assessment of thyroid hormones during and after 60-90 minutes of moderate cycling exercise.

    Related Experiment Videos

  • Analysis of free thyroxine (FT4) and thyroxine binding globulin (TBG) capacity.

    • Main Results:

    • Swimming exercise led to hemoconcentration and increased blood lactate, but not glucose levels.
    • Circulating T4, T3, and rT3 levels showed minor increases after swimming, with no significant diversion in T4 monodeiodination pathways.
    • Moderate cycling exercise had no significant effect on circulating thyroid hormone levels, FT4, or TBG capacity.

    Conclusions:

    • Brief strenuous swimming or moderate cycling exercise has minimal effects on thyroid hormone concentrations, especially when accounting for hemoconcentration.
    • Exercise does not appear to divert peripheral T4 monodeiodination from the active T3 pathway to the inactive rT3 pathway.