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Buprenorphine self-administration by rhesus monkey

N K Mello, M P Bree, J H Mendelson

    Pharmacology, Biochemistry, and Behavior
    |August 1, 1981
    PubMed
    Summary
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    Buprenorphine, a partial opiate, was self-administered by monkeys, showing it

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Buprenorphine is a partial opiate agonist and antagonist with complex pharmacological properties.
    • Understanding its reinforcing and dependence-inducing potential is crucial for its clinical application.

    Purpose of the Study:

    • To investigate the reinforcing effects of buprenorphine in rhesus monkeys.
    • To assess the dose-range, self-administration patterns, and potential for physical dependence of buprenorphine.

    Main Methods:

    • Rhesus monkeys (drug-naive and morphine-experienced) underwent intravenous self-administration of buprenorphine under a second-order schedule of reinforcement.
    • Dose-response relationships, saline substitution tests, and abrupt discontinuation were examined.
    • Behavioral observations for sedation and physical dependence signs were conducted.

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    Main Results:

    • Buprenorphine maintained operant responding across a wide dose range (0.005-0.10 mg/kg/inj).
    • Monkeys self-administered significantly more buprenorphine than saline, indicating positive reinforcement.
    • No evidence of sedation or discernible physical withdrawal signs upon abrupt discontinuation was observed.

    Conclusions:

    • Buprenorphine acts as a positive reinforcer in rhesus monkeys, maintaining behavior across various doses.
    • Despite its opiate agonist properties, buprenorphine did not produce evident physical dependence in this model.
    • These findings support buprenorphine's potential utility where abuse liability and dependence are concerns.