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Histopathologic lens changes in mirex-exposed rats

T M Scotti, N Chernoff, R Linder

Toxicology Letters

|November 1, 1981

Summary

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Mirex exposure in newborn rats causes early lens fiber swelling, progressing to degeneration and necrosis, leading to cataracts. This study details the sequential histologic changes following mirex-induced cataract development.

Area of Science:

Toxicology
Ophthalmology
Developmental Biology

Background:

Mirex, an organochlorine pesticide, is a persistent environmental contaminant.
Developmental toxicity of mirex is a concern, particularly its potential to affect offspring.
Cataracts are a significant cause of vision impairment, and understanding their induction is crucial.

Purpose of the Study:

To investigate the early histologic lesions and sequential changes in mirex-induced cataracts.
To characterize the timeline of lens damage following mirex exposure in neonatal rats.

Main Methods:

Lactating Sherman rats were administered oral mirex for five consecutive days postpartum.
Offspring were examined for histologic changes in the lens at specific neonatal time points (days 7, 9, 11, and 13).

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Main Results:

The earliest observed histologic change was slight swelling of cortical lens fibers at neonatal day 7.
By day 9, numerous swollen but intact fibers were noted.
Extensive degeneration and necrosis of lens cortex occurred by days 11 and 13.

Conclusions:

Mirex exposure during the neonatal period induces cataracts through a progressive sequence of lens fiber damage.
The findings highlight the vulnerability of developing ocular tissues to mirex toxicity.
This study provides a detailed histologic timeline of mirex-induced cataractogenesis.