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Interrelationship between vitamins E and A: a clinical study

V Jagadeesan, V Reddy

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |November 15, 1978
    PubMed
    Summary
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    Vitamin E supplementation significantly boosted plasma vitamin A levels in children, even those with vitamin A deficiency. This study highlights a potential therapeutic role for vitamin E in managing vitamin A status.

    Area of Science:

    • Pediatric Nutrition
    • Biochemistry

    Background:

    • Plasma vitamin A and E levels are crucial indicators of nutritional status in children.
    • Vitamin A deficiency is a significant global health concern, particularly in pediatric populations.
    • The interaction between vitamin E and vitamin A metabolism requires further elucidation.

    Purpose of the Study:

    • To investigate the effect of vitamin E supplementation on plasma vitamin A and E concentrations in children.
    • To determine if vitamin E influences plasma vitamin A levels in both normal and vitamin A-deficient children.

    Main Methods:

    • Cross-sectional study involving 45 children.
    • Intervention group received 100 mg of vitamin E daily for two weeks.
    • Control group received a placebo.

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  • Plasma levels of vitamin A and E were measured before and after the intervention period.

    • Main Results:

    • Baseline mean plasma vitamin E was 694 µg/dl and vitamin A was 21 µg/dl.
    • No correlation was observed between baseline plasma levels of vitamin A and E.
    • Vitamin E supplementation led to a significant increase in plasma vitamin A in both normal and deficient children.

    Conclusions:

    • Vitamin E supplementation can enhance plasma vitamin A concentrations in children.
    • This finding suggests a potential mechanism for improving vitamin A status through vitamin E intervention.
    • Further research is warranted to explore the clinical implications of this interaction.