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Related Experiment Videos

Cell surface morphology in epithelial malignancy and its precursor lesions

P Kenemans, J H Davina, R W de Haan

    Scanning Electron Microscopy
    |January 1, 1981
    PubMed
    Summary

    Scanning electron microscopy reveals cancer cells exhibit unique surface structures, like abundant microvilli, differing from normal cells. While these changes are significant for understanding oncogenesis, they currently lack early diagnostic or therapeutic value.

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    Area of Science:

    • Oncology
    • Cell Biology
    • Biotechnology

    Background:

    • Cell surface organization in cancer cells is crucial for diagnosis, prognosis, and targeted therapies.
    • Scanning electron microscopy (SEM) provides insights into cell surface morphology, vital for understanding cancer development.

    Purpose of the Study:

    • To review SEM studies on (pre)malignant cells, focusing on human cancer cells, to assess their diagnostic and prognostic potential.
    • To investigate the significance of cell surface alterations, such as microvilli, in oncogenesis and neoplastic transformation.

    Main Methods:

    • Review of existing Scanning Electron Microscopy (SEM) studies on (pre)malignant cells.
    • Analysis of cell surface morphology in vivo, in vitro, and in animal models, with a focus on human cancer cells.

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  • Examination of factors influencing cell surface morphology, including cell cycle, cell contacts, and preparation techniques.

    • Main Results:

    • Cancer cells exhibit significantly different surface morphology compared to normal cells, characterized by increased surface activity and abundant, pleomorphic microvilli.
    • In squamous epithelial cancers (e.g., bladder, cervix), microridges are replaced by microvilli during oncogenesis, increasing in number and pleomorphism.
    • SEM has significantly contributed to describing oncogenesis but currently lacks early diagnostic, prognostic, or therapeutic significance.

    Conclusions:

    • The unique surface morphology of cancer cells, particularly the presence of long, pleomorphic microvilli, may indicate neoplastic transformation.
    • Further research is needed to translate SEM-based observations into early diagnostic, prognostic, or therapeutic applications for cancer.